Elderly with proximal hip fracture present significantly lower levels of 25-hydroxyvitamin D

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• 作者：Marcelo Teodoro Ezequiel Guerra^a ; ^b ; ^{mguerraz@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Eduardo Terra Feron^b ; Roberto Deves Viana^b ; Jonathan Maboni^b ; Sté ; fany Ignê ; z Pastore^b ; Cyntia Cordeiro de Castro^b
• 关键词：Vitamin D deficiency ; Hip fractures ; Osteoporotic fractures
• 刊名：Revista Brasileira de Ortopedia (English Edition)
• 出版年：2016
• 出版时间：September-October 2016
• 年：2016
• 卷：51
• 期：5
• 页码：583-588
• 全文大小：587 K

文摘

To compare serum 25-hydroxyvitamin D (25[OH]D) levels, a serum marker of vitamin D3, between patients with and without proximal hip fracture.

Methods

This was a case–control study in which serum samples of 25(OH)D were obtained from 110 proximal hip fracture inpatients and 231 control patients without fractures, all over 60 years of age. Levels of 25(OH)D lower than or equal to 20 ng/mL were considered deficient; from 21 ng/mL to 29 ng/mL, insufficient; and above 30 ng/mL, sufficient. Sex, age, and ethnicity were considered for association with the study groups and 25(OH)D levels.

Results

Patients with proximal hip fracture had significantly lower serum 25(OH)D levels (21.07 ng/mL) than controls (28.59 ng/mL; m>pm> = 0.000). Among patients with proximal hip fracture, 54.5% had deficient 25(OH)D levels, 27.2% had insufficient levels, and only 18.2% had sufficient levels. In the control group, 30.3% of patients had deficient 25(OH)D levels, 30.7% had insufficient levels, and 38.9% had sufficient levels. Female patients had decreased serum 25(OH)D levels both in the fracture group and in the control group (19.50 ng/mL m>vsm>. 26.94 ng/mL; m>pm> = 0.000) when compared with male patients with and without fracture (25.67 ng/mL m>vsm>. 33.74 ng/mL; m>pm> = 0.017). Regarding age, there was a significant association between 25(OH)D levels and risk of fracture only for the age groups 71–75 years and above 80 years.

Conclusion

Patients with proximal hip fracture had significantly decreased serum 25(OH)D levels when compared with the control group. Female patients had significantly lower serum 25(OH)D levels in both groups.