Fragile X Syndrome Therapeutics: Translation, Meet Translational Medicine

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• 作者：Jonathan Lipton¹ ; Mustafa Sahin¹ ; ^{mustafa.sahin@childrens.harvard.edu}
• 刊名：Neuron
• 出版年：2013
• 出版时间：23 January, 2013
• 年：2013
• 卷：77
• 期：2
• 页码：212-213
• 全文大小：59 K

文摘

Fragile X syndrome, a common cause of intellectual disability and autism, is thought to occur due to abnormal regulation of neuronal protein synthesis. A study by , in this issue, demonstrates that the HMG-CoA reductase inhibitor lovastatin can normalize protein synthesis and also reduce audiogenic seizures in Fmr1 knockout mice.