Emerging Roles of Adipose Progenitor Cells in Tissue Development, Homeostasis, Expansion and Thermogenesis

详细信息    查看全文

• 作者：Daniel C. Berry¹ ; Yuwei Jiang¹ ; Jonathan M. Graff¹ ; ² ; ^{jon.graff@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：adipose tissue ; stem cells ; niche ; obesity ; perivascular cells ; beige/brite adipocytes
• 刊名：Trends in Endocrinology & Metabolism
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：27
• 期：8
• 页码：574-585
• 全文大小：1840 K

文摘

Stem or progenitor cells are an essential component for the development, homeostasis, expansion, and regeneration of many tissues. Within white adipose tissue (WAT) reside vascular-resident adipose progenitor cells (APCs) that can proliferate and differentiate into either white or beige/brite adipocytes, which may control adiposity. Recent studies have begun to show that APCs can be manipulated to control adiposity and counteract ‘diabesity’. However, much remains unknown about the identity of APCs and how they may control adiposity in response to homeostatic and external cues. Here, we discuss recent advances in our understanding of adipose progenitors and cover a range of topics, including the stem cell/progenitor lineage, their niche, their developmental and adult roles, and their role in cold-induced beige/brite adipocyte formation.