Predictive Value of Retinal Morphology for Visual Acuity Outcomes of Different Ranibizumab Treatment Regimens for Neovascular AMD

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• 作者：Sebastian M. Waldstein ; MD¹ ; Jonathan Wright ; MSc² ; James Warburton ; MBBS³ ; Philippe Margaron ; PhD³ ; Christian Simader ; MD ; MSc¹ ; Ursula Schmidt-Erfurth ; MD¹ ; ^{ursula.schmidt-erfurth@meduniwien.ac.at" class="auth_mail" title="E-mail the corresponding author}
• 关键词：AMD ; age-related macular degeneration ; BCVA ; best-corrected visual acuity ; CATT ; Comparison of Age-Related Macular Degeneration Treatments Trials ; CRT ; central retinal thickness ; EXCITE ; Efficacy and Safety of Ranibizumab in Patients with Subfoveal Choroidal Neovascularization Secondary to Age-Related Macular Degeneration ; IRC ; intraretinal cystoid fluid ; nAMD ; neovascular age-related macular degeneration ; OCT ; optical coherence tomography ; PED ; pigment epithelial detachment ; PRN ; pro re nata ; P
• 刊名：Ophthalmology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：123
• 期：1
• 页码：60-69
• 全文大小：1160 K

文摘

To establish the predictive value of defined retinal morphologic parameters on visual outcomes and re-treatment needs in patients with neovascular age-related macular degeneration (nAMD) receiving ranibizumab treatment.

Design

Post hoc analysis of a prospective, 12-month, multicenter, phase IIIb trial.

Participants

Three hundred fifty-three treatment-naïve patients with nAMD.

Methods

Available data from 319 treatment-naïve patients receiving ranibizumab 0.3 mg monthly (frequent regimen; n = 102) or ranibizumab 0.3 or 0.5 mg quarterly (pooled 0.3/0.5 mg = infrequent regimen; n = 217) were analyzed to assess the correlations between baseline retinal morphologic parameters and best-corrected visual acuity (BCVA) change (structure–function correlations). The BCVA was measured at monthly visits. Optical coherence tomography scans were acquired monthly for quantitative measures of the central retinal thickness and qualitative assessment of retinal morphologic features. Assessed morphologic parameters included intraretinal cystoid fluid (IRC), subretinal fluid (SRF), pigment epithelial detachment, and vitreomacular interface configuration classification comprising vitreomacular adhesion and posterior vitreous detachment (PVD). An analysis of covariance was conducted to evaluate the impact of retinal morphologic features on BCVA change at month 12.

Main Outcome Measures

Change in BCVA from baseline to month 12 compared between frequent and infrequent treatment arms.

Results

Relevant predictive factors for BCVA change at month 12 were baseline SRF (P = 0.05), PVD (P = 0.03), IRC (P = 0.05), treatment frequency (P < 0.01), and BCVA (P < 0.01). The presence of both SRF and PVD at baseline was associated with similar BCVA gains regardless of treatment frequency (mean difference in BCVA gains at month 12 of +2.6 letters in favor of infrequent treatment). Subretinal fluid was present in 71% of patients, and PVD was present in 64% of patients.

Conclusions

In patients with both SRF and PVD at baseline, similar BCVA outcomes were observed regardless of treatment frequency. These patients may require less frequent treatments compared with patients without SRF, without PVD, or without either who may require more frequent injections for maintenance of vision. This finding may have implications in clinical practice by helping to tailor an individualized re-treatment interval in nAMD patients.