Simultaneous production of high specific activity ⁶⁴Cu and ⁶¹Co with 11.4 MeV protons on enriched ⁶⁴Ni nuclei

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• 作者：Miguel A. Avila-Rodriguez ; Jonathon A. Nye ; Robert J. Nickles
• 关键词：Cobalt-61 ; Copper-64 ; Simultaneous production ; High specific activity ; Low energy cyclotron
• 刊名：Applied Radiation and Isotopes
• 出版年：2007
• 出版时间：October 2007
• 年：2007
• 卷：65
• 期：10
• 页码：1115-1120
• 全文大小：183 K

文摘

The ⁶⁴Cu and ⁶¹Co radionuclides were produced simultaneously by irradiation of enriched ⁶⁴Ni on a low energy proton-only cyclotron. Nickel targets were prepared by electrodeposition of enriched ⁶⁴Ni (>95 % ) on Au backing at thicknesses of 25–225 mg/cm² with efficiencies >99 % . Irradiations up to 30 μA for 8 h were performed with 11.4 MeV protons using a water-cooled target mounting. Radiochemical separation of ⁶⁴Cu and ⁶¹Co from ⁶⁴Ni was performed by chromatography of the chlorocomplexes in a single step using an anion exchange resin column with a yield >95 % . Using this method, the Ni target material was recovered and re-plated for subsequent production runs with an overall efficiency >96 % . The excitation function for the ⁶⁴Ni(p,n)⁶⁴Cu reaction was measured and compared with published values. Experimental thick target saturation yields of 159 mCi/μA for ⁶⁴Cu and 715 μCi/μA for ⁶¹Co were achieved. Typical specific activities of ⁶⁴Cu were found to be 18.8±3.3 Ci/μmol.