Production and separation of non-carrier-added ⁸⁶Y from enriched ⁸⁶Sr targets

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• 作者：Miguel A. Avila-Rodriguez ; Jonathon A. Nye ; Robert J. Nickles
• 关键词：Yttrium-86 ; Non-carrier-added separation ; Yttrium-90 surrogate ; Low-energy cyclotron
• 刊名：Applied Radiation and Isotopes
• 出版年：2008
• 出版时间：January 2008
• 年：2008
• 卷：66
• 期：1
• 页码：9-13
• 全文大小：229 K

文摘

The metallic radionuclide ⁸⁶Y was produced by irradiation of enriched ⁸⁶SrCO₃ on a low-energy proton-only cyclotron. Irradiations up to 20 μA for 2 h were performed with 11 MeV protons using a water-cooled target mounting with circulating chilled helium. Experimental thick target yields of 26.7 mCi/μA yielded 24 mCi of ⁸⁶Y in 2 h of bombardment at 10 μA. The difference in solubility products between Y(OH)₃ and Sr(OH)₂ allows the separation of ⁸⁶Y from an alkaline strontium solution by using filter paper with an overall yield of 88±3 % . The concentration of Sr in the final product was found to be on the order of 15 ppm when using 200 mg of target material as determined by ICP-MS analysis. The reactivity of ⁸⁶Y was determined to be on the order of 1.5±0.8 Ci/μmol of DOTA. The enriched target material was recovered and converted to its original chemical form with an overall efficiency >90 % .