Astroglial d-serine is the endogenous co-agonist at the presynaptic NMDA receptor in rat entorhinal cortex
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- 作者：Alex M. Lencha ; Peter V. Masseya ; Loredano Pollegionib ; Gavin L. Woodhallc ; Roland S.G. Jonesa ; r.s.g.jones@bath.ac.uk" class="auth_mail
- 关键词：Entorhinal cortex ; Presynaptic NMDA receptor ; Glycine ; d-Serine ; Glutamate release ; Astroglia
- 刊名：Neuropharmacology
- 出版年：August 2014
- 年：2014
- 卷：83
- 期：Complete
- 页码：118-127
- 全文大小：613 K
文摘
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We investigate the co-agonist regulation of the presynaptic NMDA autoreceptor.
Agonists/antagonists studies show it is tonically activated and close to saturation.
Enzyme depletion studies show mallcaps">d-serine is likely to be the endogenous co-agonist.
Astroglial provide the endogenous mallcaps">d-serine that occupies the presynaptic receptor.