PEG-modified chondroitin sulfate A-deoxycholic acid (CSD) conjugate was synthesized.
Doxorubicin (DOX)-loaded CSD-PEG nanoparticles (NPs) were prepared and characterized.
CD44 receptor-mediated endocytosis of NPs was identified in ovarian cancer cells.
PEGylation of NPs provided a decreased clearance of drug after intravenous injection.