The prognostic significance of glomerular infiltrating leukocytes during acute renal allograft rejection
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- 作者：Alexis Sentí ; sa ; b ; 1 ; Jesper Kersa ; 1 ; j.kers@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author ; Unsal Yapicia ; Nike Claessena ; Joris J.T.H. Roelofsa ; Frederike J. Bemelmanc ; Ineke J.M. ten Bergec ; 2 ; Sandrine Florquina ; 2
- 关键词：ABMR ; antibody-mediated rejection ; TCMR ; T cell-mediated rejection ; C4d ; complement factor 4d ; HLA ; human leukocyte antigen ; ROC ; receiver operating characteristics ; AUC ; area under the curve ; DSA ; donor-specific antibodies ; MPNS ; methylprednisolone ; ATG ; anti-thymocyte globulin ; CDC ; complement dependent cytotoxicity ; PRA ; panel reactive antibodies ; IF/TA ; interstitial fibrosis and tubular atrophy ; OR ; odds ratio ; HR ; hazard ratio ; IQR ; interquartile range ; IFN ; interferon ; DBD ; deceased after
- 刊名：Transplant Immunology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：33
- 期：3
- 页码：168-175
- 全文大小：1095 K
文摘
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During acute rejection, 96% of biopsies had at least some degree/form of glomerulitis.
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Glomerulitis is mainly composed of T cells, (IL-17+) neutrophils and macrophages.
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None of the quantified cell types appeared to be a good biomarker for the response to antirejection therapy.
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Macrophage glomerulitis has a predictive value for graft failure until 500 days after rejection.