Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition

详细信息    查看全文

• 作者：Valentine Comaills¹ ; ³ ; Lilian Kabeche¹ ; Robert Morris¹ ; Ré ; mi Buisson¹ ; Min Yu¹ ; ⁶ ; Marissa Wells Madden¹ ; Joseph A. LiCausi¹ ; Myriam Boukhali¹ ; Ken Tajima¹ ; ³ ; Shiwei Pan¹ ; Nicola Aceto¹ ; ⁷ ; Srinjoy Sil¹ ; Yu Zheng¹ ; ² ; Tilak Sundaresan¹ ; ⁴ ; Toshifumi Yae¹ ; ³ ; Nicole Vincent Jordan¹ ; ² ; David T. Miyamoto¹ ; ⁴ ; David T. Ting¹ ; ⁴ ; Sridhar Ramaswamy¹ ; ⁴ ; Wilhelm Haas¹ ; Lee Zou¹ ; ⁵ ; Daniel A. Haber¹ ; ² ; ⁴ ; Shyamala Maheswaran¹ ; ³ ; ⁸ ; ^{maheswaran@helix.mgh.harvard.edu}
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：6 December 2016
• 年：2016
• 卷：17
• 期：10
• 页码：2632-2647
• 全文大小：4079 K
• 卷排序：17

文摘

Persistent cell proliferation during TGF-β-induced EMT results in cytokinesis failure Mitotic defects during EMT lead to genomic instability and tumorigenic phenotypes Modulation of LaminB1 phenocopies the defects in cells undergoing EMT Genomic instability is prevalent in mesenchymal CTCs compared with epithelial CTCs