Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer鈥檚 disease presenting as logopenic progressive aphasia

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• 作者：Keith A. Josephs ; Dennis W. Dickson ; Melissa E. Murray ; Matthew L. Senjem ; Joseph E. Parisi ; Ronald C. Petersen ; Clifford R. Jack Jr. ; Jennifer L. Whitwell
• 关键词：Primary progressive aphasia ; Logopenic variant of primary progressive aphasia ; Alzheimer&rsquo ; s disease ; Neurofibrillary tangles ; Hippocampus ; MRI ; Apolipoprotein E ; TDP-43 ; Voxel-based morphometry ; Alzheimer&rsquo ; s dementia
• 刊名：Brain and Language
• 出版年：November, 2013
• 年：2013
• 卷：127
• 期：2
• 页码：127-134
• 全文大小：1638 K

文摘

Neurofibrillary tangles (NFTs) are one of the key histological lesions of Alzheimer鈥檚 disease (AD) and are associated with brain atrophy. We assessed regional NFT density in 30 patients with AD, 10 of which presented as the logopenic variant of primary progressive aphasia (lvPPA) and 20 that presented as dementia of the Alzheimer鈥檚 type (DAT). Regional grey matter volumes were measured using antemortem MRI. NFT density was significantly higher in left temporoparietal cortices in lvPPA compared to DAT, with no differences observed in hippocampus. There was a trend for the ratio of temporoparietal-to-hippocampal NFT density to be higher in lvPPA. The imaging findings mirrored the pathological findings, with smaller left temporoparietal volumes observed in lvPPA compared to DAT, and no differences observed in hippocampal volume. This study demonstrates that lvPPA is associated with a phenomenon of enhanced temporoparietal neurodegeneration, a finding that improves our understanding of the biological basis of lvPPA.