Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia

详细信息    查看全文

• 作者：Lili Wang¹ ; ¹¹ ; ¹⁵ ; Angela N. Brooks¹ ; ² ; ³ ; ¹⁵ ; Jean Fan⁴ ; ¹⁵ ; Youzhong Wan¹ ; ¹³ ; ¹⁵ ; Rutendo Gambe¹ ; Shuqiang Li⁷ ; Sarah Hergert¹ ; Shanye Yin¹² ; Samuel S. Freeman² ; Joshua Z. Levin² ; Lin Fan² ; Michael Seiler¹⁴ ; Silvia Buonamici¹⁴ ; Peter G. Smith¹⁴ ; Kevin F. Chau¹¹ ; Carrie L. Cibulskis² ; Wandi Zhang¹ ; Laura Z. Rassenti⁶ ; Emanuela M. Ghia⁶ ; Thomas J. Kipps⁶ ; Stacey Fernandes¹ ; Donald B. Bloch¹⁰ ; Dylan Kotliar¹¹ ; Dan A. Landau¹ ; ¹¹ ; Sachet A. Shukla¹ ; Jon C. Aster⁸ ; Robin Reed¹² ; David S. DeLuca² ; Jennifer R. Brown¹ ; ⁹ ; Donna Neuberg⁵ ; Gad Getz² ; Kenneth J. Livak⁷ ; Matthew M. Meyerson¹ ; Peter V. Kharchenko⁴ ; Catherine J. Wu¹ ; ² ; ⁹ ; ¹¹ ; ¹⁶ ; ^{cwu@partners.org" class="auth_mail" title="E-mail the corresponding author}
• 关键词：CLL ; SF3B1 ; Notch signaling ; RNA sequencing ; alternative splicing
• 刊名：Cancer Cell
• 出版年：2016
• 出版时间：14 November 2016
• 年：2016
• 卷：30
• 期：5
• 页码：750-763
• 全文大小：4966 K

文摘

<dl class="listitem" id="list_ulist0010"><dt class="label">•dt><dd>

d="p0010">SF3B1 mutation causes alternative splicing in cell lines and primary CLL cells

dd><dt class="label">•dt><dd>

d="p0015">SF3B1 mutation-associated splice variants are enriched for 3′ splice sites

dd><dt class="label">•dt><dd>

d="p0020">SF3B1 mutation induces RNA changes affecting multiple CLL-associated pathways

dd><dt class="label">•dt><dd>

d="p0025">SF3B1 mutation modulates Notch signaling through an RNA splice variant of DVL2

dd>dl>