Antimitochondrial antibodies in patients with epilepsy

详细信息    查看全文

• 作者：Jouni Ranua ; Katja Luoma ; Anssi Auvinen ; Anna-Maija Haapala ; Markku M&#xe4 ; ki ; Jukka Peltola ; Jani Raitanen and Jouko I. Isoj&#xe4 ; rvi
• 关键词：Antimitochondrial antibodies ; Autoimmunity ; Epilepsy
• 刊名：Epilepsy & Behavior
• 出版年：2005
• 出版时间：2005
• 年：2005
• 卷：7
• 期：1
• 页码：95-97
• 全文大小：106 K

文摘

Immune mechanisms have been implicated in the pathogenesis of epilepsy. An increased prevalence of autoantibodies, as well as changes in serum immunoglobulin concentrations, has been reported in patients with epilepsy. The presence of unspecific antimitochondrial antibodies (AMAs) and their possible associations with other immunological markers were evaluated in a cohort of 1386 adult patients with epilepsy and population-based reference subjects. Unspecific AMAs were more frequent in epilepsy patients than in the reference group. Thirty-seven epilepsy patients (3.9 % ) and eleven control subjects (1.9 % ) had unspecific AMAs (RR 2.1, CI 1.05–4.1, P = 0.03). These antibodies were associated with long duration of epilepsy and old age at the onset of epilepsy among patients with epilepsy. Their presence was independent of other immunological markers, comorbidity, and epilepsy medications.