ULK1 and ULK2 mediate phosphorylation of the COPII scaffold protein SEC16A at S846
ULKs (not ATG13) regulate SEC16A-dependent ER-to-Golgi trafficking of specific cargo
ULK1/2 deficiency causes ER stress and selective loss of hippocampal neurons.
Restoring ER-to-Golgi trafficking in ULK-deficient cells quells the ER stress response