Keloids: Animal models and pathologic equivalents to study tissue fibrosis
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- 作者：Jaana Marttalaa ; &dagger ; ; Jonathan P. Andrewsa ; &dagger ; ; Joel Rosenblooma ; b ; c ; Jouni Uittoa ; c ; jouni.uitto@jefferson.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：HS ; hypertrophic scar ; IGF-1 ; insulin-like growth factor-1 ; IL ; Interleukin ; ROS ; reactive oxygen species ; SSc ; systemic sclerosis ; TGF-β ; transforming growth factor-β
- 刊名：Matrix Biology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：51
- 期：Complete
- 页码：47-54
- 全文大小：1012 K
文摘
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Genetic animal models with diffuse skin fibrosis have been encountered, including tight skin mutant mouse (TSK) 1 and 2.
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Trauma-induced scarring and chemically-induced fibrosis can serve as models for fibrotic diseases.
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Keloids, the paradigm of fibrotic skin diseases, are uniquely human, and there are no naturally occurring animal models.
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Implantation of biodegradable 3-D scaffolds with human cells into mice has been developed as an in vivo model of keloids.
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Availability of animal models for fibrotic diseases allows testing of novel anti-fibrotic pharmacologic agents