Keloids: The paradigm of skin fibrosis ‿Pathomechanisms and treatment
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- 作者：Jonathan P. Andrewsa ; &dagger ; ; Jaana Marttalaa ; &dagger ; ; Edward Macaraka ; b ; Joel Rosenblooma ; b ; Jouni Uittoa ; c ; jouni.uitto@jefferson.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ECM ; extracellular matrix ; Fn-EDA ; fibronectin extra domain A ; MMPs ; metalloproteinases ; PAI-I ; plasminogen activator inhibitor-I ; PDGF ; platelet-derived growth factor ; TLRs ; toll-like receptors ; TGF-β ; transforming growth factor-β ; VEGF ; vascular endothelial growth factor
- 刊名：Matrix Biology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：51
- 期：Complete
- 页码：37-46
- 全文大小：985 K
文摘
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Keloids are dermal tumors characterized by excessive accumulation of collagen.
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The key cell responsible for matrix production is activated myofibroblast.
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A number of growth factors, particularly TGF-β, play a role in excessive collagen production.
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Recent studies have supported a role for Fibronectin Extra Domain A (Fn-EDA) which is markedly upregulated in keloids.
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Identification of pathways involved in matrix accumulation allows development of targeted therapies for fibrotic diseases.