PGC-1 coactivators in 尾-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids
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- 作者：Daniel Oropeza
- 关键词：Beta cell ; PGC-1 ; Insulin secretion ; Lipid metabolism ; Mitochondria ; Lipolysis
- 刊名：Molecular Metabolism
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：4
- 期：11
- 页码：811-822
- 全文大小：3102 K
文摘
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- <p id="p0010">Loss of Pgc-1s in adult 尾-cells decreases insulin secretion in response to glucose/palmitate.p>
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- <p id="p0015">Pgc-1伪/尾 is not required to maintain basal mitochondrial mass or oxidative capacity in mature 尾-cells.p>
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- <p id="p0020">Pgc-1伪/尾 regulates expression of the lipolytic enzymes HSL and ATGL in 尾-cells.p>
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- <p id="p0025">Reduced 尾-cell Pgc-1 causes accumulation of intracellular acyl-glycerols and cholesterol esters.p>