Therapeutic angiogenesis for revascularization in peripheral artery disease

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• 作者：Anna Grochot-Przeczek ; Jozef Dulak ; Alicja Jozkowicz
• 关键词：AdVEGF ; adenoviral vector encoding vascular endothelial growth factor ; aFGF ; acidic fibroblast growth factor ; Ang-1 ; angiopoietin 1 ; bFGF ; basic fibroblast growth factor ; BMDCs ; bone marrow-derived cells ; BVR ; biliverdin reductase ; Del-1 ; developmental en
• 刊名：Gene
• 出版年：2013
• 出版时间：10 August, 2013
• 年：2013
• 卷：525
• 期：2
• 页码：220-228
• 全文大小：268 K

文摘

Therapeutic angiogenesis for peripheral artery disease (PAD), achieved by gene and cell therapy, has recently raised a great deal of hope for patients who cannot undergo standard revascularizing treatment. Although pre-clinical studies gave very promising data, still clinical trials of gene therapy have not provided satisfactory results. On the other hand, cell therapy approach, despite several limitations, demonstrated more beneficial effects but initial clinical studies must be constantly validated by larger randomized, multi-center, double-blinded, placebo-controlled trials. This review focuses on previous and recent gene and cell therapy studies for limb ischemia, including both experimental and clinical research, and summarizes some important papers published in this field. Moreover, it provides a short comment on combined gene and cell therapy approach on the example of heme oxygenase-1 overexpressing cells with therapeutic properties.