Identification of new binding sites of human transferrin incubated with organophosphorus agents via Q Exactive LC-MS/MS
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- 作者：Fengjuan Sun fengjuan_sun@163.com" class="auth_mail" title="E-mail the corresponding author ; Junjie Ding djj224@163.com" class="auth_mail" title="E-mail the corresponding author ; Huilan Yu yuhuilan1@163.com" class="auth_mail" title="E-mail the corresponding author ; Runli Gao gaorunli@163.com" class="auth_mail" title="E-mail the corresponding author ; Hongmei Wang ; wanghongmei@dicp.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Chengxin Pei ; chengxin.ricd@yahoo.com.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：amu ; atomic mass unit ; CAM ; carbamidomethyl ; cyclosarin ; O-cyclohexyl methylphosphonofluoridate ; ethyl tabun ; N ; N-diethyl O-ethyl phosphorocyanidate ; GI ; geninfo Identifier ; HCD ; high-energy collision-induced dissociation ; MS/MS ; tandem mass spectrometry fragmentation ; m/z ; mass divided by charge ; MWCO ; molecular weight cutoff ; NCBI ; national center for biotechnology information ; OPs ; organophosphorus agents ; propyl tabun ; N ; N-dipropyl O-ethyl phosphorocyanidate ; Q Exactive LC&ndash ; MS/MS ; Q Exa
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：1022
- 期：Complete
- 页码：256-264
- 全文大小：1882 K
文摘
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Three kinds of labeled adducts found in the manuscript enlarge the field of targets of human transferrin.
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Q-Exactive LC–MS/MS is a useful method for identifying phosphylation of protein.
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The characteristic ions of tyrosine and lysine adducts described in this article should aid in the discovery of proteins and peptides labeled by OPs.