Prevalence of Metabolic Syndrome and its Components in Patients With Acute Coronary Syndrome

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• 作者：Ana Jover^a ; Emili Corbella^b ; Anna Muñ ; oz^c ; Jes&#xfa ; s Millá ; n^d ; Xavier Pintó ; ^b ; Alipio Mangas^e ; Manuel Z&#xfa ; ñ ; iga^f ; Juan Pedro-Botet^g ; Antonio Herná ; ndez-Mijares^a ; ^h ; ^{Antonio.Hernandez@uv.es"" rel=""nofollow}
• 关键词：Metabolic syndrome X ; Coronary disease ; High-density lipoproteins ; Diabetes mellitus ; Obesity
• 刊名：Revista Española de Cardiología (English Edition)
• 出版年：2011
• 出版时间：July 2011
• 年：2011
• 卷：64
• 期：7
• 页码：579-586
• 全文大小：147 K

文摘

Introduction and objectives

A large proportion of patients with coronary disease have metabolic syndrome, although the frequency and association of its different components are not well understood. The aim of this study was to determine the prevalence of metabolic syndrome and the combination of its components in a Spanish cohort of patients with acute coronary syndrome.

Methods

Clinical histories of 574 inpatients with acute coronary syndrome in 6 tertiary hospitals were reviewed and the presence of metabolic syndrome and its components determined by applying Adult Treatment Panel III criteria. In a second step, the components of the metabolic syndrome were analyzed, excluding those patients with diabetes mellitus.

Results

The metabolic syndrome was present in 50.9 % of patients and was more frequent in women than in men (66.3 % vs. 47.3 % ; P < .001). The most prevalent component was carbohydrate metabolism disorder (85.3 % ), followed by low high-density lipoprotein cholesterol (HDLc) levels (80.5 % ). In nondiabetic patients, 34.6 % had metabolic syndrome and the most prevalent component was low HDLc levels (86 % ), followed by high blood pressure and hypertriglyceridemia and, in fourth place, impaired fasting serum glucose levels.

Conclusions

The metabolic syndrome has a high prevalence in patients with an acute coronary syndrome, especially in women. The most frequent components are hyperglycemia and low HDLc levels. After excluding diabetic patients, the most prevalent diagnostic criterion of metabolic syndrome was low HDLc levels.