• 作者：Juan José ; Castó ; n^a ; ^{juanjoco2005@yahoo.es} ; Marí ; a José ; Linares^b ; Antonio Rivero^c ; Manuel Casal^b ; Juliá ; n Torre-Cisneros^c
• 关键词：Aspergilosis ; Enfermedad pulmonar obstructiva cr&oacute ; nica ; Asma bronquial ; Fibrosis pulmonar ; Factor de riesgo ; Fluconazol
• 刊名：Medicina Cl¡§anica
• 出版年：2012
• 出版时间：15 December, 2012
• 年：2012
• 卷：139
• 期：15
• 页码：668-671
• 全文大小：198 K

Background and objetive

To determine clinical variables to distinguish invasive pulmonary aspergillosis (IPA) from colonization in patients with chronic pneumopathies with positive culture of Aspergillus spp. in respiratory samples.

Patients and methods

Retrospective cohort study including patients with respiratory isolations of Aspergillus spp. during a period of 10 years. IPA was evaluated according to the Bulpa criteria. Clinical variables were collected and a multiple logistic regression analysis was carried out.

Results

Eighty-three patients with isolation of Aspergillus spp. from respiratory samples were included; 68.7 % (n = 57) of the patients had chronic obstructive pulmonary disease, 18 % (n = 15) pulmonary fibrosis and 13.3 % (n = 11) bronchial asthma. Twenty-two patients (26.6 % ) had IPA. The use of fluconazole (OR 4.49; CI 95 % 1.5-13.4; P = .007), severe respiratory failure (OR 4.64; CI 95 % 1.46-14.72; P = .009) and hospitalization time (OR 1.05; CI 95 % 1.01-1.1; P = .006) were associated with IPA.

Conclusions

Prior use of fluconazole, severe respiratory failure and hospitalization time are associated with IPA in patients with chronic pneumopathies with respiratory isolation of Aspergillus spp.