Prevalence of monosodium urate deposits in a population of rheumatoid arthritis patients with hyperuricemia

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• 作者：Christina Petsch^a ; Elizabeth G. Araujo ; MD^a ; Matthias Englbrecht ; Dipl Psych^a ; Sara Bayat ; MD^a ; Alexander Cavallaro ; MD^b ; Axel J. Hueber ; MD ; PhD^a ; Michael Lell ; MD^b ; Georg Schett ; MD^a ; Bernhard Manger ; MD^a ; Juergen Rech ; MD^a ; ^{juergen.rech@uk-erlangen.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Rheumatoid arthritis ; Gout ; Monosodium urate ; Hyperuricemia ; Dual energy computed tomography
• 刊名：Seminars in Arthritis and Rheumatism
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：45
• 期：6
• 页码：663-668
• 全文大小：946 K

文摘

To investigate the prevalence of monosodium urate (MSU) crystal deposits, indicative for gout, in a population of rheumatoid arthritis (RA) patients with concomitant hyperuricemia and to analyze the clinical and disease-specific characteristics of RA patients who exhibit MSU crystal deposits.

Methods

Overall, 100 consecutive patients with the diagnosis of RA and a serum urate level above 6 mg/dl underwent dual energy computed tomography (DECT) of both feet and hands to search for MSU crystals in a prospective study between October 2011 and July 2013. Presence and extent of MSU crystal deposits on DECT was assessed by automated volume measurement. Demographic and disease-specific characteristics were recorded and included into two logistic regression models to test for the factors associated with MSU crystal deposits in RA.

Results

Hyperuricemic RA patients were mostly male (55%), over 60 years of age (63 ± 11 years), had established disease (8.7 ± 10.5 years) and a mean disease activity score 28 (DAS 28) of 3.2. In total, 20 out of 100 patients displayed MSU crystal deposits in DECT. Interestingly, the majority (70%) of the RA patients positive for MSU crystal deposits were seronegative RA patients. Hence, every third seronegative RA patient had MSU crystal deposits. According to logistic regression model analysis, seronegative status correlated positively with presence of urate deposits (p = 0.019).

Conclusions

These data show that a considerable number of RA patients display periarticular MSU crystal deposits. Seronegative patients were shown to be predominantly affected with every third patient being positive for urate deposits.