TPH2 gene variation and conflict processing in a cognitive and an emotional Stroop task

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• 作者：Roman Osinsky ; Anja Schmitz ; Nina Alex ; er ; Yvonne Kuepper ; Eva Kozyra ; Juergen Hennig
• 关键词：Executive control ; Stroop task ; Conflict processing ; Serotonin ; TPH2 − ; 703 G/T ; Genes
• 刊名：Behavioural Brain Research
• 出版年：2009
• 出版时间：17 March 2009
• 年：2009
• 卷：198
• 期：2
• 页码：404-410
• 全文大小：521 K

文摘

Evidence suggests that a promoter polymorphism of the tryptophan-hydroxylase 2 gene (TPH2 −703 G/T) is associated with executive control functions. The current study aimed to clarify whether this relation is restricted to a purely cognitive domain or whether such an effect can also be observed in the processing of emotional material. In a sample of 89 student subjects, a ‘cognitive’ and an ‘emotional’ Stroop paradigm were applied to measure processing of cognitive and affective conflicts. Our results suggest an impact of the TPH2 −703 G/T polymorphism on executive control in both, the cognitive as well as the emotional task. In detail, homozygous carriers of the T allele showed decelerated responses in low-conflict conditions, pointing to a rather abnormal functioning of higher-order control mechanisms. Thus, the present investigation is consistent with previous behavioural studies and adds further evidence for the impact of serotonin at the interface of cognition and emotion.