Semantic dementia combined with motor neuron disease
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- 作者：Sook Hui Kim ; Sang Won Seo ; Seok Min Go ; Mee Kyung Suh ; Juhee Chin ; Jee Hyang Jeong ; Duk L. Na
- 关键词：Motor neuron disease ; Positron emission tomography (PET) ; Semantic dementia
- 刊名：Journal of Clinical Neuroscience
- 出版年：2009
- 出版时间：December 2009
- 年：2009
- 卷：16
- 期：12
- 页码：1683-1685
- 全文大小：297 K
文摘
Up to 20 % of patients with behavioural variants of frontotemporal dementia (FTD) also have motor neuron disease (MND); conversely, this comorbidity is rare in patients with language variants of FTD. A few patients have been reported with semantic dementia (SD) combined with MND. However, these patients demonstrated the clinical features of MND in the advanced stage. We report a patient with SD who also demonstrated MND symptoms in an earlier stage of the disease. A 61-year-old man visited our memory disorder clinic as a result of language disturbance and dysarthria of 8 months duration and facial recognition impairment of 3 months duration. Neuropsychological tests revealed anomic aphasia, prosopagnosia, and decreased semantic fluency. A brain MRI revealed significant atrophies localized in both anterior temporal lobes with a greater prominence on the right side. Clinical examination and electrophysiological studies confirmed a diagnosis of MND 17 months after the onset of the disease.