Hippocampal and cortical atrophy in amyloid-negative mild cognitive impairments: comparison with amyloid-positive mild cognitive impairment
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- 作者：Byoung Seok Ye ; Sang Won Seo ; Chi Hun Kim ; Seun Jeon ; Geon Ha Kim ; Young Noh ; Hanna Cho ; Cindy W. Yoon ; Hee Jin Kim ; Eun Young Jang ; Jeongmin Lee ; Jung-Hyun Kim ; Juhee Chin ; Jong Min Lee ; Jeong-Hun Kim ; Joon-kyung Seong ; Chang-Hun Kim ; Yearn Seong Choe ; Kyung Han Lee ; Duk L. Na ; et al.
- 关键词：Mild cognitive impairment ; Alzheimer's disease ; Pittsburgh compound B ; Cortical thickness ; Hippocampus
- 刊名：Neurobiology of Aging
- 出版年：February, 2014
- 年：2014
- 卷：35
- 期：2
- 页码：291-300
- 全文大小：1550 K
文摘
Although patients with amnestic mild cognitive impairment (aMCI) are at higher risk of developing Alzheimer's disease (AD), their pathologies could be heterogeneous. We aimed to evaluate structural changes in amyloid-negative and amyloid-positive aMCI patients. Forty-eight aMCI patients who underwent Pittsburgh compound B (PiB) positron emission tomography were recruited. They were classified as PiB (鈭? aMCI (N聽= 16) and PiB (+) (N聽= 32). Hippocampal shape and regional cortical thickness were compared with 41 subjects with normal cognition (NC). Relative to NC, PiB(鈭? aMCI exhibited hippocampal deformity in the right cornu ammonis 1, whereas PiB(+) aMCI exhibited hippocampal deformity in bilateral subiculum and cornu ammonis 1 subregions. Relative to NC, PiB(鈭? aMCI showed cortical thinning in the left medial prefrontal and right anterior temporal regions, whereas PiB(+) aMCI exhibited cortical thinning in bilateral medial temporal regions, temporoparietal junctions and precuneus, and prefrontal cortices. Our findings suggest that structural changes in PiB(鈭? aMCI might be due to several possible pathologic changes, whereas structural changes in PiB(+) aMCI reflect AD-like structural changes.