Transcriptional control of epidermal specification and differentiation

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• 作者：Dai ; Xing ; Segre ; Julia A
• 关键词：IFE ; interfollicular epidermis ; K ; keratin ; SC ; stem cell ; TA ; transit-amplifying ; TF ; transcription factor
• 刊名：Current Opinion in Genetics & Development
• 出版年：2004
• 出版时间：October, 2004
• 年：2004
• 卷：14
• 期：5
• 页码：485-491
• 全文大小：576 K

文摘

Recent experiments reveal the role of transcription factors in integrating upstream signals to execute specification and differentiation of epidermal cells. Based on the skin phenotype observed with misregulation of transcription factors such as p63, c-Myc, RelA, pRb, Klf4 and others, their function in controlling proliferation and differentiation is dissected. Understanding the pathways regulated by these factors and their coordinate interactions remains a challenge for the future.