Low Radiation Dose and Low Cell Dose Increase the Risk of Graft Rejection in a Canine Hematopoietic Stem Cell Transplantation Model
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- 作者：Sandra Lange1 ; sandra.lange@med.uni-rostock.de" class="auth_mail" title="E-mail the corresponding author ; Anne Steder1 ; Ä ; nne Glass2 ; Doreen Killian1 ; Susanne Wittmann1 ; Christoph Machka1 ; Juliane Werner1 ; Stephanie Schä ; fer1 ; 3 ; Catrin Roolf1 ; Christian Junghanss1
- 关键词：Allogeneic hematopoietic stem cell transplantation ; Low-dose irradiation ; Graft rejection ; Chimerism ; Nonmyeloablative ; Dog
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：22
- 期：4
- 页码：637-643
- 全文大小：604 K
文摘
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Risk factors for graft rejection were determined in the canine transplantation model.
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Low radiation dose (≤2 Gy) was a significant risk factor for graft rejection.
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TNC cell count <5 × 108/kg was a significant risk factor for graft rejection.
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Novel immunosuppression using RAD/CSA and RAD/MMF did not reduce graft rejection.
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Blood chimerism at day +28 post-transplantation was predictive of long-term engraftment.