The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair
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- 作者：Julian Lange1 ; Shintaro Yamada1 ; 2 ; Sam E. Tischfield1 ; 3 ; Jing Pan1 ; 7 ; Seoyoung Kim1 ; Xuan Zhu1 ; 4 ; Nicholas D. Socci5 ; Maria Jasin4 ; 6 ; m-jasin@ski.mskcc.org" class="auth_mail" title="E-mail the corresponding author ; Scott Keeney1 ; 2 ; 4 ; 8 ; s-keeney@ski.mskcc.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：meiosis ; homologous recombination ; double-strand break ; resection ; DNA damage ; DNA repair ; chromatin ; mouse ; SPO11 ; PRDM9
- 刊名：Cell
- 出版年：2016
- 出版时间：20 October 2016
- 年：2016
- 卷：167
- 期：3
- 页码：695-708.e16
- 全文大小：5955 K
文摘
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Hierarchical combinations of factors shape DSB landscapes at small and large scales
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Local chromatin structure strongly shapes DSB distributions
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Exonucleolytic DSB resection averages 900 base pairs with wide variation
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ATM plays a dominant role in molding genome-wide DSB distributions