Systems Analysis of the Dynamic Inflammatory Response to Tissue Damage Reveals Spatiotemporal Properties of the Wound Attractant Gradient
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- 作者：Helen Weavers1 ; 3 ; 7 ; Juliane Liepe2 ; 7 ; Aaron Sim2 ; Will Wood3 ; Paul Martin1 ; 4 ; 5 ; 6 ; 8 ; paul.martin@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Michael P.H. Stumpf2 ; 8 ; m.stumpf@imperial.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Current Biology
- 出版年：2016
- 出版时间：8 August 2016
- 年：2016
- 卷：26
- 期：15
- 页码：1975-1989
- 全文大小：7256 K
文摘
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Computational modeling of in vivo inflammatory response to tissue damage is applied
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The model infers novel spatiotemporal properties of the wound attractant gradient
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Wound signal is released from the wound edge for 30 min and diffuses at 200 μm2/min
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Modeling two competing wounds reveals a period of immune cell desensitization