Down-regulation of purinergic P2X7 receptor expression and intracellular calcium dysregulation in peripheral blood mononuclear cells of patients with amyotrophic lateral sclerosis
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- 作者：Jingyu Liu ; Tino Prell ; Tino.Prell@med.uni-jena.de" class="auth_mail" title="E-mail the corresponding author ; Beatrice Stubendorff ; Silke Keiner ; Thomas Ringer ; Anne Gunkel ; Vedrana Tadic ; Nadine Goldhammer ; Ayse Malci ; Otto W. Witte ; Julian Grosskreutz
- 关键词：Amyotrophic lateral sclerosis ; Peripheral blood mononuclear cells ; Purinergic receptors ; Calcium homeostasis
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：6 September 2016
- 年：2016
- 卷：630
- 期：Complete
- 页码：77-83
- 全文大小：1863 K
文摘
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Expression of purineric receptors (P2X4 and P2X7) and intracellular Ca2+ changes were analyzed in PBMCs of ALS patients.
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We observed a downregulation of P2X7 receptors in PBMCs of ALS patients compared to controls.
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Intracellular Ca2+ dysregulation as a main characteristic of motor neurons in ALS is detectable in PBMCs.
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Stimulation of PBMCs with different concentrations of ATP revealed decreased intracellular Ca2+ levels in ALS patients.