Resveratrol-loaded poly(ε-caprolactone) nanocapsules increase the drug stability.

Enhanced in vitro and in vivo anticancer activity using a murine melanoma model.

Resveratrol-loaded nanocapsules were effective to reduce cell viability at higher concentrations.

This formulation led to a significant reduction in tumor volume.

Increased necrotic area and inflammatory infiltrate of melanoma tumor and avoid metastasis.