Rapid decomposition of peroxynitrite by manganese porphyrin-antioxidant redox couples

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• 作者：Lee ; Jinbo ; Hunt ; Julianne A. ; Groves ; John T.
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：1997
• 出版时间：November 18, 1997
• 年：1997
• 卷：7
• 期：22
• 页码：2913-2918
• 全文大小：368 K

文摘

Mn(III)TMPyP reacts rapidly with the toxic oxidant peroxynitrite (ONOO⁻) to generate an oxoMn(IV) species, but Mn(III)TMPyP is not catalytic for ONOO⁻ decomposition due to the slow reduction of oxoMn(IV) back to the Mn(III) oxidation state. However, when redox-coupled with biological antioxidants that efficiently reduce oxoMn(IV), Mn(III)TMPyP is transformed into an efficient “peroxynitrite reductase.”