Amphiphilic peroxynitrite decomposition catalysts in liposomal assemblies

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• 作者：Hunt ; Julianne A. ; Lee ; Jinbo ; Groves ; John T.
• 关键词：membrane self-assembly ; metalloporphyrins ; peroxynitrite ; sterically stabilized liposomes
• 刊名：Chemistry & Biology
• 出版年：1997
• 出版时间：November, 1997
• 年：1997
• 卷：4
• 期：1
• 页码：845-858
• 全文大小：1.54 M

文摘

Background: Peroxynitrite (ONOO⁻), a toxic biological oxidant, has been implicated in many pathophysiological conditions. The water-soluble porphyrins 5,10,15,20-tetrakis(N-methyl-4′-pyridyl)porphinato iron(III) (FeTMPyP) and manganese(III) (MnTMPyP) have recently emerged as potential drugs for ONOO⁻ detoxification, and FeTMPyP has demonstrated activity in models of ONOO⁻ related disease states. We set out to develop amphiphilic analogs of FeTMPyP and MnTMPyP suitable for liposomal delivery in sterically stabilized liposomes (SLs).