Impact of recommendations on the initial therapy of Parkinson’s disease: A population-based study in France

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• 作者：Claudine Fayard^a ; Audrey Bonaventure^b ; ^c ; Isabelle Benatru^a ; Emmanuel Roze^d ; Julien Dumurgier^b ; ^c ; ^e ; Fré ; dé ; ric Moisan^b ; ^c ; Aï ; cha Soumaré ; ^b ; ^c ; Jean Houssinot^f ; Jean-Luc Dupupet^f ; Jean-Louis Mazurie^g ; Irina Balaboi^h ; Jean-Luc Houeto^h ; Elsa Krimⁱ ; Daniè ; le Ranoux^j ; Marcel Goldberg^k ; ^l ; ^m ; Ellen Imbernonⁿ ; Thibault Moreau^a ; Maurice Giroud^a ; Christophe Tzourio^b ; ^c ; Alexis Elbaz^b ; ^c ; ^{alexis.elbaz@upmc.fr"" rel=""nofollow}
• 关键词：Parkinson&#x2019 ; s disease ; Guidelines ; Epidemiology ; Medical practice
• 刊名：Parkinsonism and Related Disorders
• 出版年：2011
• 出版时间：August 2011
• 年：2011
• 卷：17
• 期：7
• 页码：543-546
• 全文大小：138 K

文摘

Levodopa induces long-term motor complications in Parkinson&#x2019;s disease (PD). Therapeutic strategies that prevent motor complications are needed. Our aim was to evaluate the impact of recommendations of a French consensus conference published in 2000 on initial PD therapy. We identified 308 PD patients as part of a population-based study performed within the Mutualité Sociale Agricole in five French districts (2007). Neurologists confirmed PD diagnosis. We compared initial therapy in 102 patients treated before 12/31/2000 to that of 206 patients treated afterwards. Initial treatment was in agreement with the recommendations if dopamine agonists were used in patients <60 years (n&#xa0;=&#xa0;49) and levodopa in patients ≥70 years (n&#xa0;=&#xa0;133). Agreement with the recommendations increased after 2000 (66.0 % ) compared to before (46.3 % , p&#xa0;=&#xa0;0.025). For patients <60 years, agreement increased (64.0 % vs 20.2 % , p&#xa0;=&#xa0;0.017) while it remained stable (66.4 % vs 70.6 % , p&#xa0;=&#xa0;0.73) in patients ≥70 years. The publication of recommendations has influenced initial treatment choices for PD in France.