This study first investigated the association among DNMT1 and DNMT3B polymorphisms with Parkinson Disease (PD) and showed an original result. The DNMT3B polymorphism rs2424913 was associated with Parkinson’s Disease (PD). The presence of the T allele increased the odds ratio to PD. No significant difference was observed for others SNPs investigated in DNMT3B and DNMT1. This association suggests a role for a DNA methylation enzyme in PD, highlighting the hypothesis of epigenetic mechanisms to PD pathogenesis.