Functional characterization of six aspartate (D) recombinant mojastin mutants (r-Moj): A second aspartate amino acid carboxyl to the RGD in r-Moj-D_ peptides is not sufficient to induce apoptosis of SK-Mel-28 cells.
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- 作者：Carla J. Ramosa ; Daniel A. Gutierreza ; Ana S. Arandaa ; Melissa A. Koshlaychuka ; David A. Carrilloa ; Rafael Medranoa ; Terri D. McBridea ; Andrew Ua ; Stephanie M. Medinaa ; Melissa C. Lombardoa ; Sara E. Lucenab ; Elda E. Sanchezb ; Julio G. Sotoa ; julio.soto@sjsu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Melanoma cell line ; Recombinant RGD disintegrin ; αvβ3 integrin ; αv knockdown ; Cell migration ; Cell proliferation ; Apoptosis induction ; rac-1 expression
- 刊名：Toxicon
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：118
- 期：Complete
- 页码：36-42
- 全文大小：1081 K
文摘
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r-Moj-DL, r-Moj-DM, and r-Moj-DN induced apoptosis of SK-Mel-28 cells.
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All r-Moj-D_ mutant peptides antagonize the αv integrin subunit.
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All r-Moj-D_ peptides inhibited cell proliferation and cell migration.
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All, but r-Moj-DV, treatments resulted in the downregulation of rac-1 expression.