RNA sequence analyses of r-Moj-DM treated cells: TXNIP is required to induce apoptosis of SK-Mel-28
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- 作者：Terri D. McBride ; U. Andrew ; Nicko Ly ; Julio G. Soto ; Julio.Soto@sjsu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：RNA sequencing ; Recombinant RGD disintegrin ; TXNIP knockdowns ; Cell viability ; TXNIP protein localization
- 刊名：Toxicon
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：121
- 期：Complete
- 页码：1-9
- 全文大小：1120 K
文摘
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40 genes were differentially expressed as a result of r-Moj-DM treatment.
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Expression of 6 pro-apoptotic genes was higher in r-Moj-DN treated cells.
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TXNIP is involved in the apoptotic induction activated by r-Moj-DM.
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GST-Moj-DM binding to SK-Mel-28 results in integrin clustering.
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GST-Moj-DM binding results in TXNIP nuclear translocation.