Transforming growth factor-β1 regulation of ATF-3, c-Jun and JunB proteins for activation of matrix metalloproteinase-13 gene in human breast cancer cells

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• 作者：M. Gokulnath¹ ; R. Swetha¹ ; G. Thejaswini¹ ; P. Shilpa ; N. Selvamurugan ; Ph. D. ; ^{selvamurugan.n@ktr.srmuniv.ac.in} ; ^{selvamn2@yahoo.com} (Professor)
• 关键词：ATF-3 ; TGF-β1 ; MMP-13 ; c-Jun ; JunB ; Breast cancer
• 刊名：International Journal of Biological Macromolecules
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：94
• 期：part_PA
• 页码：370-377
• 全文大小：2102 K
• 卷排序：94

文摘

TGF-β1 stimulated expression of MMP-13 (an invasive and metastasis gene) via ATF-3 in human breast cancer cells. TGF-β1 stimulated ATF-3 interaction at the AP-1 site of the MMP-13 promoter in a sustained and prolonged manner. TGF-β1 stimulated the ATF-3 interaction and regulation of c-Jun and JunB proteins. The presence of c-Jun/ATF-3 complex at the AP-1 site of the MMP-13 promoter in MDA-MB231 cells upon TGF-β1-treatment.