iPSC-Derived Retina Transplants Improve Vision in rd1 End-Stage Retinal-Degeneration Mice

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• 作者：Michiko Mandai¹ ; ^{mmandai@cdb.riken.jp} ; Momo Fujii¹ ; Tomoyo Hashiguchi¹ ; Genshiro A. Sunagawa¹ ; Shin-ichiro Ito¹ ; Jianan Sun¹ ; Jun Kaneko¹ ; Junki Sho¹ ; Chikako Yamada¹ ; Masayo Takahashi¹
• 关键词：retinal regeneration ; photoreceptor transplantation ; iPSC ; retinal degeneration ; multiple electrode array ; shuttle-avoidance test
• 刊名：Stem Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：8
• 期：1
• 页码：69-83
• 全文大小：5645 K
• 卷排序：8

文摘

iPSC retina reconstructs outer nuclear layer in the end-stage retina Contacts between the host bipolar cells and graft photoreceptors were visualized rd1 mice became responsive to light after iPSC-retina transplantation RGC responses to light were recorded from host rd1 retina after transplantation