Shikonin derivatives: synthesis and inhibition of human telomerase

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• 作者：Lu ; Qun ; Liu ; Weijun ; Ding ; Jian ; Cai ; Junchao ; Duan ; Wenhu
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2002
• 出版时间：May 20, 2002
• 年：2002
• 卷：12
• 期：10
• 页码：1375-1378
• 全文大小：113 K

文摘

We synthesized dl-shikonin, shikonin, alkanin, and their cyclo-derivatives and acyl-derivatives. These compounds have low cytotoxicity, as well as inhibitory activity against the telomerase enzyme, except cyclo-derivatives.