The adaptor protein Cindr regulates JNK activity to maintain epithelial sheet integrity
详细信息 查看全文
- 作者：Hannah W.R. Yasin1 ; Samuel H. van Rensburg1 ; Christina E. Feiler1 ; 2 ; Ruth I. Johnson ; rijohnson@wesleyan.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CP ; actin-capping protein ; AJ ; adherens junction ; APF ; after puparium formation ; A/P ; anterior/posterior ; Bsk ; basket ; β-Gal ; β-Galactosidase ; JNK ; c-Jun N-terminal kinase ; Chic ; chickadee ; Dcr-2 ; dicer-2 ; D/V ; dorsal/ventral ; dJNK ; Drosophila JNK ; Jra or dJun ; Drosophila Jun ; Ecad ; ecadherin ; GMA ; GFP ; moesin-Actin-binding-domain ; GFP ; green fluorescent protein ; GAPs ; GTPase activating proteins ; Hid ; hid involution defective ; MMP ; matrixmetalloprotease ; Ptc ; patched ; Puc ; puckered ; RTK ; receptor
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：410
- 期：2
- 页码：135-149
- 全文大小：7574 K
文摘
- •
Reducing expression of the adaptor protein Cindr compromised epithelial integrity.
- •
Cells with reduced Cindr delaminated: some migrated short distances; most died.
- •
JNK activity mediated the behavior of cells lacking Cindr.
- •
Cindr complexed with dJNK to repress its signaling activity.
- •
The correct stoichiometry of Cindr-dJNK complexes maintains epithelial integrity.