Lesions of the lateral habenula facilitate active avoidance learning and threat extinction

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• 作者：Mihee Song¹ ; Yong Sang Jo¹ ; Yeon-Kyung Lee ; June-Seek Choi ; ^{j-schoi@korea.ac.kr}
• 关键词：Lateral habenula ; Two-way active avoidance ; Fear conditioning ; Extinction ; Reinforcement learning ; Rat
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：318
• 期：Complete
• 页码：12-17
• 全文大小：1136 K
• 卷排序：318

文摘

LHb was damaged to study its role in avoidance and threat learning. LHb lesions facilitated two-way active avoidance learning. LHb lesions had no effects on the acquisition of conditioned threat responses. LHb lesions accelerated the extinction of conditioned threat memory.