Efficacy of Ablation Therapy for Secondary Hyperparathyroidism by Ultrasound Guided Percutaneous Thermoablation
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- 作者：Junfeng Zhao ; Linxue Qian ; qianlinxue2002@163.com" class="auth_mail" title="E-mail the corresponding author ; Yuan Zu ; Ying Wei ; Xiangdong Hu
- 关键词：Secondary hyperparathyroidism ; Serum parathyroid hormone ; Thermal ablation ; Ultrasound
- 刊名：Ultrasound in Medicine & Biology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：42
- 期：5
- 页码：1058-1065
- 全文大小：1206 K
文摘
The objective of this study was to explore the value of ultrasound-guided percutaneous microwave thermoablation to treat secondary hyperparathyroidism (SHPT). One hundred and thirty-eight parathyroid glands from 56 patients with SHPT were ablated in this study. All the parathyroid glands were evaluated by real-time contrast-enhanced ultrasound before, during and after ablation. Changes in serum parathyroid hormone (sPTH) levels were measured before treatment and at 1 h, 1 wk, 1 mo and 6 mo after thermoablation treatment. All 56 cases had a 1-mo follow-up, and 34 cases had a 6-mo follow-up. The sPTH level of the 54 cases 1 mo after ablation was significantly lower than that before (p < 0.05). In the 34 cases that had a 6-mo follow-up, the sPTH levels were also significantly lower at 6 mo after ablation than before (p < 0.05). Bone pain in patients improved post-operatively (p < 0.05), but itchiness and insomnia did not improve (p > 0.05). Ultrasound-guided percutaneous microwave thermoablation is a feasible and effective non-surgical alternative treatment for SHPT patients.