ID1 suppresses CULLIN3, which activates GSC self-renewal via SHH and WNT signaling
CULLIN3 regulates ubiquitin-mediated degradation of DVL2 and GLI2 proteins
The combined controls of GLI2 and β-CATENIN effectively suppress GSC properties
The ID1hi/CULLIN3lo signature correlates with poor prognosis of GBM patients