Epigenetic age signatures in the forensically relevant body fluid of semen: a preliminary study
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- 作者：Hwan Young Lee ; hylee192@yuhs.ac" class="auth_mail" title="E-mail the corresponding author ; Sang-Eun Jung ; Yu Na Oh ; Ajin Choi ; Woo Ick Yang ; Kyoung-Jin Shin
- 关键词：Forensic science ; Age ; DNA methylation ; Semen ; TTC7B ; NOX4
- 刊名：Forensic Science International: Genetics
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：19
- 期：Complete
- 页码：28-34
- 全文大小：431 K
文摘
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Previously reported age predictors were tested using 450K array data for 36 body fluid samples.
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Age-related CpG candidates were selected from the array results of 12 semen samples.
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Age-predictability of selected CpGs was tested in 68 semen samples.
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Age-predictive model generated with 3 CpGs showed prediction error of approximately 5 years.
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The CpG sites in the TTC7B gene and the NOX4 gene showed high age prediction capability.