Focal adhesion kinase regulation in stem cell alignment and spreading on nanofibers
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- 作者：Mohammad Nahid Andaliba ; 1 ; Jeong Soon Leea ; 1 ; Ligyeom Haa ; Yuris Dzenisa ; ydzenis@unl.edu" class="auth_mail" title="E-mail the corresponding author ; Jung Yul Lima ; b ; jlim4@unl.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aligned and random nanofibers ; Mesenchymal stem cells ; Cell alignment and spreading ; Focal adhesion kinase ; shRNA
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：13 May 2016
- 年：2016
- 卷：473
- 期：4
- 页码：920-925
- 全文大小：1592 K
文摘
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Use aligned and random nanofibers at the same fiber diameter with proper flat control.
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FAK expression and phosphorylation are increased by aligned and random nanofibers.
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Elongated and well-spread morphologies on aligned and random nanofibers, respectively.
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FAK-shRNA suppresses MSC elongation and spreading on nanofibrous cultures.