Interplay of Endosomal pH and Ligand Occupancy in Integrin α5β1 Ubiquitination, Endocytic Sorting, and Cell Migration
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- 作者：Dmitri Kharitidi1 ; 4 ; Pirjo M. Apaja2 ; 4 ; Sanaz Manteghi1 ; Kei Suzuki3 ; Elena Malitskaya1 ; Ariel Roldan2 ; Marie-Claude Gingras1 ; Junichi Takagi3 ; Gergely L. Lukacs1 ; 2 ; 5 ; gergely.lukacs@mcgill.ca" class="auth_mail" title="E-mail the corresponding author ; Arnim Pause1 ; 5 ; arnim.pause@mcgill.ca" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：20 October 2015
- 年：2015
- 卷：13
- 期：3
- 页码：599-609
- 全文大小：3262 K
文摘
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Endosomal pH regulates dissociation of integrin α5β1 and fibronectin dissociation
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Ligand occupancy is a determinant for α5β1-complex ubiquitination
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HD-PTP and UBAP1 are required for ubiquitinated α5β1 lysosomal targeting
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HD-PTP depletion accelerates α5β1 recycling and cell migration