Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy
详细信息 查看全文
- 作者：Toshihiro Kurahashia ; 1 ; Jaeyong Leea ; Atsunori Nabeshimab ; Takujiro Hommaa ; Eun Sil Kanga ; Yuka Saitoa ; Sohsuke Yamadab ; 2 ; Toshiyuki Nakayamab ; Ken-ichi Yamadac ; d ; Satoshi Miyatae ; Junichi Fujiia ; jfujii@med.id.yamagata-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acetaminophen ; Ascorbic acid ; Glutathione ; Amino acid transporter ; Autophagy
- 刊名：Archives of Biochemistry and Biophysics
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：604
- 期：Complete
- 页码：36-46
- 全文大小：2097 K
文摘
- •
AAP-induced liver damage was exacerbated in AsA-deficient mice.
- •
AsA effectively ameliorated AAP-induced liver damage in AsA-deficient mice.
- •
AsA deficiency delayed the recovery of the GSH level in AAP treated mice liver.
- •
Cysteine supply systems were induced in mice liver after AAP treatment.
- •
The induction of the cysteine supply systems was impaired in AsA-deficient mice.