Sodium nitrite attenuates hypertension-in-pregnancy and blunts increases in soluble fms-like tyrosine kinase-1 and in vascular endothelial growth factor
详细信息 查看全文
- 作者：Victor Hugo Gonç ; alves-Rizzi ; Jose Sergio Possomato-Vieira ; Tamiris Uracs Sales Graç ; a ; Regina Aparecida Nascimento ; Carlos A. Dias-Junior ; carlosjunior@ibb.unesp.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hypertension-in-pregnancy ; Sodium nitrite ; N(G)-nitro-l-arginine methyl ester ; Rats
- 刊名：Nitric Oxide
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：57
- 期：Complete
- 页码：71-78
- 全文大小：591 K
文摘
- •
Sodium nitrite prevents hypertension-in-pregnancy induced by L-NAME.
- •
Sodium nitrite reduces circulating sFlt-1 and VEGF levels in pregnancy hypertension.
- •
Sodium nitrite improves litter size with more viable fetuses and placental weight.
- •
The effects of sodium nitrite may be due to nitrite-derived NO formation.
- •
Sodium nitrite exerts antioxidant effects by mechanisms not entirely known.