HMGB1-RAGE signaling pathway in severe preeclampsia
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- 作者：Linlin Zhua ; b ; Zhan Zhanga ; c ; d ; e ; zhangzhanmd@126.com" class="auth_mail" title="E-mail the corresponding author ; Linlin Zhanga ; d ; e ; Ying Shia ; Jiahui Qid ; e ; Aimin Changd ; e ; Junjun Gaoa ; Yang Fengd ; Xiaoqian Yangd
- 关键词：Severe preeclampsia ; HMGB1 ; RAGE ; NF-魏B ; Placenta ; Inflammation
- 刊名：Placenta
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：36
- 期：10
- 页码：1148-1152
- 全文大小：662 K
文摘
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125 placenta samples were detected uniformly by tissue microarray technology.
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The mRNA and protein expression of HMGB1–RAGE pathway were increased in severe PE.
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Up-regulated HMGB1 expression in maternal serum was detected simultaneously.
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Migration of HMGB1 from nucleus to cytoplasm in severe PE was discovered.